Here's an idea we could use: Take inspiration from
Doctor Who's relationship between River Song and the Doctor.
Massive
Doctor Who spoilers ahead, of course.
The main thing about their tragic relationship is that they are temporally out of sync. The first time the Doctor meets River is the last time River sees the Doctor, before she sacrifices herself to save him. Since
DW is a series about time travel, the two meet again many times, in the Doctor's future and River's past. That's why it's tragic. The Doctor always knows that River will die.
I think there's a lot here to be played around with. A story from "River's" perspective? A similar tragic relationship between the hero and villain even? What do y'all think?