See, Chrono's comment assumes that there was a difference in the time line. It's possible that there's an infinite loop that occurs at that same point in time every time the timeline occurs, assuming that Marle always disappears after a certain amount of time, whether or not Crono appears to help her. If the Queen goes missing again, isn't it safe to assume the search for her would continue and Frog would still find her? No, we can't say for sure, but I think we could assume. Remember, Lucca says "As I remember, someone was supposed to save her, but it appears that we've changed time" when Marle disappears.
So, if Marle disappears, and Frog recovers Leene, Marle reappears but never makes it back to her own period, there is only a minor alteration to the timeline since her ancestors still survive and are able to keep reproducing and (Eventually) she's born again to repeat the same events (Which, like I said, would continue in a loop forever).
Temporal Inertia doesn't necessarily have any effect here, because we're ignoring the duration of time and merely speaking about the entire act itself (As I understand the TI theory).