Those goddamn piranhas...Oh, wait, no RD love? Not actually a 'boss'? Whatever...
Anyways...Ocean Palace Lavos, Golem, Golem Twins & sorta Golem Boss (I didn't know he would run!)...And Zeal with her fuckass Hallation move...Pink Nu Spekkio for obvious reasons (if you don't have Frog or Robo to heal your whole party, you're kind of screwed [I refuse to use items on a boss that heals you completely even if you lose])...
Nu Master from CTDS is certainly one of the series hardest opponents right up there with Lavos & Pink Nu Spekkio...Oh and those two new demon bosses that regenerate if you don't kill them both at the same time put a strain on me as well because at first I thought one was a reviver like the Lavos Core, so I focused on the other one and then BLAMMO, it came right back...and my team wasn't set up real well elementally at the time to properly deal with them both so I just had to figure out in my head how much HP & damage I was dealing to kill them both off close enough in time not to screw myself...The fight was probably the longest I've fought in the series, I think...V_V
No one in CC really...Miguel was a close call though, certainly...Had to dig deep to keep my party alive in that one (all the way in Sprigg's Dodo form grid for that extra Revive Element), but that might be because I brought Harle along for the ride (but MoonShine helps goddamn it, I swear!)...