Well, ZealKnight, a question for you:
What evolutionary influence did Lavos or the Frozen Flame have on humans?
From CC, it is clearly stated that there was some influence, but we can see that other than being able to use magic, Ayla is essentially the same as Lucca. Because of this, the ability to use Magic is generally seen to be that influence. Now, we'd have a bit of an evolutionary conundrum: two very similar genetic traits evolved in two completely separate species due to completely different circumstances. While not impossible, it is improbable.
As for the Lost Sanctum, I must confess I haven't played CTDS yet. I am currently working on correctly that gap in my knowledge and hopefully will be better able to comment soon.